Globalism is one of important subject in present era, that is one of important knot and makes problem.Recognition the real significance of Globalization, how to gain real Globalization , the ways for oppose with Globalizations the main goal of Globalization and the way of entry to Globalization, is the main subjects and important that this article try to discuss them. Reversion to opinion and toughts of religion leader for answer to these questions, is very important .the main subject of this article is the matter of the signicance of Globalization in the opinion of Ayatollah khamenei and the matter of global best manage in beam of special mention of the Islamic Republic of Iran,s policy. With this element. The collection of speechs and statements from the beginning of appointment as a leader to yet , is as a statistic society. Researchers in this article with the use of container analysis style, the orient and his emphasise point , survey and categorise and show that is in the opinion of Ayatollah khamenei, Globalization, universalize and generalize, all of them are tempter topics and arrived from the vest that as a quasi liberal manner they, enter to the culture of the countries and the goal of all of these, is dominance to vitol and financial sources of all the world and swallow most of the world. There fore, in his opinion, correct realization to Globalization, need to manage arena of vicissitude of the world for example the protect of independence of the countlies, exigency defiance of cultural economic, politic busis.